MELOXICAM-INDUCED GASTROPATHY IN DOGS: CLINICAL, BIOCHEMICAL, ENDOSCOPIC FEATURES AND TRIALS FOR PREVENTION

This study was conducted to evaluate and compare the clinical, hemato-biochemical endoscopic aspects of gastropathy in dogs treated with meloxicam alone or incombination esomeprazole misoprostol. Twenty baladi healthy were included experimental study. Dogs divided into four groups each group consisting five animals; Group I (control group), that does not receive any medication. Meloxicam into: II which received at a dose 0.2 mg/kg BWT per OS /24 hr. III animals same previous 1mg/kg IV misoprostol 3μg /kg tid. Upon drug administration, kept under observation for 14 consecutive days. Clinical analysis evaluated across time (T0, T3, T7, T10 T14). The image gastroscopic examination T7 T14), examinations applied all three points lesions scored by use 5-point scale. Clinically, most common clinical sings induced- inappetence anorexia, hematemesis, melena, abdominal pain weakness, specific gastric erosion, hemorrhage ulcers. Serum gastrin concentration is biochemically sensitive indicator gastropathy. overall results concluded meloxicam-induced more severe compared IV. proton pump inhibitor (esomeprazole) effective better tolerated than